Finding the Best Fit: Bayesian Statistics Meets Geometry

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Guest Commentary by Dr. Martyn Rittman

A common problem faced in research is when a set of data has been collected on the one hand, and a theoretical model (a set of equations with input parameters) exists on the other. We want to know firstly, whether the model describes the data well and secondly, what variables of the model give the best possible fit.

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Nanoporous Xerogels “Sniff Out” Bad Bacteria

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XerogelBacteria were among the first life forms to appear on the face of the Earth and have the uncanny ability to overcome even the harshest of environments, from acidic hot springs to the ice-fields of the poles and deep portions of the Earth’s crust. They are so abundant, that they make up the majority of the total biomass on earth. Astonishingly, nearly 90% of the cells that move around with humans are actually bacteria [1], though since they are so much smaller than human cells, they make up only about 10 percent of our body-weight. Continue reading

MDPI Magazine: The First Year

The MDPI Magazine was started a year ago with an idea to provide an overview of recently published papers from MDPI journals that are of broad interest for the natural science community, particularly those in the life sciences. In this way, and reflecting the growing trend in inter- and multi-disciplinary research, the Magazine aims to raise awareness of current advances in a wide range of scientific disciplines.

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In Silico Docking of Bolinaquinone at Clathrin Terminal Domain

Guest Commentary by Derek McPhee

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Endocytosis is a fundamental process that delivers macromolecules located outside the cell or on the cell membrane to the cytoplasm. It is a necessary process for nutrients to reach the cell, and for regulation of numerous transmembrane receptors. Of the various ways whereby cargo can access the cytoplasm, one of the most researched is the so called clathrin-dependent endocytosis, whose mechanism is relatively well understood. Membrane fragments, along with their contents, enter the cell as vesicles coated with clathrin species. This activity is not only key to the survival and normal functioning of eukaryotic cells, but has also been associated with a variety of pathological states, such as the access of pathogens like virus and bacteria to the cell interior, a number of cancers and other conditions.

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